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Clinical Diabetes 25:135-140, 2007
DOI: 10.2337/diaclin.25.4.135
© 2007 by the American Diabetes Association
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Feature Article

Weight-Loss Pharmacotherapy: A Brief Review

Mary Margaret Huizinga, MD, MPH

IN BRIEF

The medical treatment of obesity is aimed at decreasing appetite, alterating absorption of calories, and increasing thermogenesis. Two agents are available for the long-term treatment of obesity: sibutramine, a centrally acting anorectic agent, and orlistat, which blocks the absorption of fat by inhibiting the enzyme lipase. Agents approved for short-term treatment include the central anorectic agents phentermine and diethylpropion. Other agents, including endocannabinoid system antagonists, anti-epileptic agents, and combination therapies, are under investigation.


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Copyright © 2007 by the American Diabetes Association.