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Clinical Diabetes 24:88-89, 2006
© American Diabetes Association ®, Inc., 2006

Landmark Study

Glycemic Control and Cardiovascular Disease in Patients With Type 1 Diabetes

K.M. Venkat Narayan, MD, MPH, FRCP, FACP

The first 20% of the full text of this article appears below.


   STUDY
 
The DCCT/EDIC Study Research Group: Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med353 : 2643-2653,2005[Abstract/Free Full Text]


   SUMMARY
 
Objective. To investigate whether the use of intensive glycemic control versus conventional therapy during the Diabetes Control and Complications Trial (DCCT) affected the long-term incidence of cardiovascular disease (CVD).

Design. The DCCT randomly assigned 1,441 patients with type 1 diabetes to intensive or conventional therapy, treating them for a mean of 6.5 years. Ninety-three percent were subsequently followed for CVD in the Epidemiology of Diabetes Interventions and Complications (EDIC) study.

Setting. Multicenter study in the United States.

End points. CVD was defined as nonfatal myocardial infarction, stroke, death from CVD, confirmed angina, or the need for coronary artery revascularization.

Results. At the end of the DCCT, after 6.5 years of treatment, mean hemoglobin A1c (A1C) was 7.4% in the intensive group and 9.1% in the conventional group. After an additional 11 years of follow-up, during which the conventional group received more intensive therapy, A1C levels were 7.9 and 7.8% in the DCCT intensive and conventional groups, respectively. Intensive treatment . . . [Full Text of this Article]


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Clin. Diabetes 2006 24: 51-53. [Extract] [Full Text] [PDF]





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